Objective: To compare a sensitivity, specificity and accuracy of ASB RealTime PCR detecting T1799A mutation assay with that of FNAC. Subject and method: A total of 45 thyroid nodules from patients were prospectively analyzed for their cytology. A final diagnosis was confirmed by histologic after thyroidectomy. brafT1799A mutation was analysed by ASB RealTime PCR. A sensitivity, specificity and accuracy of ASB RealTime PCR assay was determined base on the results of histopathology. Result A sensitivity, specificity and accuracy of ASB RealTime PCR assay was 92.3 percent; 83.3 percent and 91.1 percent compare with that of 90.5 percent; 33.3 percent and 88.8 percent which was determined by FNAC. Conclusion: brafT1799A mutation analysis when combine with FNAC can significantly improve FNAC diagnostic accuracy.
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