Castleman's disease is a raJ:e disease of lymphoid hyperplasia. Objective: A report on 4 Castleman's cases diagnosed and treated at department of haematological diseases of No.108 military central hospital from 2011 to 2013 and review of the literature, Patients and method: restrospective case series, describred clinical and paraclinical manifestations, treatment and response of 4 Castleman's patients. Result: All 4 patients were multicentric diseases in which once with multiple neck Iympho nodes, 3 remains had more Iympho nodes in abdomen and 1 had also Iympho nodes in mediastinum. Fatigues and enlarged neck Iympho nodes were found in all 4 patients. Abdominal and chest pains were found in patients with enlarged abdominal and mediastinal Iympho nodes. Systemic chemotherapy with CHOP regimen were done for all 4 patients. All patients were good responsed and survival until time report. Conclusion: Castleman's disease is a poorly understood disease that create diagnostic dilemmas for physician. The histological hyalin-vascular type usually presents unicentric in clinical, thought the plasma cell type is more commonly multicentric than unicentric. A complete clinical, histological and immunohistochemical analysis is essential to obtain a definite and differential diagnosis. Complete surgical resection of unicentric disease is likely to afford the best chance for cure. Combined chemotherapies such as CHOP for muticentric disease should be used and which gave good response.
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