Objective: To describe the current Ebola virus epidemic and the potential options for management of Ebola virus disease. Data sources: A PubMed literature search (1976 through January, 2014) was conducted using the search term Ebola. Study selection and data extraction: Epidemiology, clinical trial studies, CDC and WHO reports published in English were selected. Studies published within the past 5 years were the primary focus of this review. Data synthesis: The current Ebola virus epidemic has primarily been contained in West Africa though it has subsequently spread to other areas, including the United States. Treatment options for patients infected with Ebola virus are limited. Supportive therapy is centered on fluid resuscitation, electrolyte imbalance correction, treating complicating infections, and preventing complications of shock. Experimental therapies (ZMapp, brincidofovir, TKM-Ebola, and favipiravir) have been used during this current outbreak. Different vaccine therapies are also in early-stage development. Conclusion: Ebola virus is highly virulent and fatal, and treatment options are limited. Several experimental and existing therapies may be options for preventing and treating Ebola virus disease.
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