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Collation of EGFR (Her-1) expression with clinical features in sinonasal squamous cell carcinoma

nckh
Thông tin nghiên cứu
Loại tài liệu
Bài báo trên tạp chí khoa học (Journal Article)
Tiêu đề
Collation of EGFR (Her-1) expression with clinical features in sinonasal squamous cell carcinoma
Tác giả
Nguyễn Đình Phúc; Tống Xuân Thắng; Phan Thanh Dự; Lê Trung Thọ
Năm xuất bản
2014
Số tạp chí
1
Trang bắt đầu
5-10
ISSN
1859-3704
Abstract

Prognosis of sinonasal squamous cell carcinoma (SNSCC) depends on TNM staging, histologic categories and expression of cell-surface receptors (p53, Ki 67, EGFREpidermal Growth Factor Receptor (ErbB-1; HER1...). Objectives: 1- Determine the rate of EGFR expression in biopsy samples and 2- Collate the rate of EGFR expression with clinical features in SNSCC. Materials and Methods: Prospective case study on thirty-two SNSCC patients treated at National ENT Hospital in two years (2011-2012). Clinical presentations, CT scan imaging were analysed and biopsy samples were categorised to investigate EGFR expression (Her-1). Results and Discussions: The rate of EGFR expression in SNSCC was 53.1 percent, with 25 percent was scored 3+. EGFR was postive in 50 percent (16/32) stage III patients (21,4 percent was scored 3+) and 75 percent (3/4) stage IV patients (50 percent was scored 3+). The EGFR-positive rate was higher in exophytic, advanced stage with neurologic deficits and cerviallymphadenopathy. Conclusions: The EGFR was positive in 53,1 percent of sino nasal squamous cell carcinoma.