Cortisol huyết thanh, nồng độ TSH, FT3, FT4 ở những bệnh nhân bị đột quỵ xuất huyết não trong 72 giờ đầu

Objective: To investigating concentrations of serum cortisol, TSH, FT3 and FT4, and assess the relationships between these concentrations and the disease's severity in patients with hemorrhage stroke during the first 72 hours. Subject and method: the authors performed a cross sectional study in 44 patients with hemorrhage stroke during the first 72 hours and 31 healthy controls. Result: the concentrations of serum TSH and FT3 of the hemorrhage stroke group were significantly lower than those of control group (1.0 +/- 0.8uUI/mL versus 1.9 +/- 1.0uUI/mL; p0.001; 2.6 +/- 0.5pg/mL versus 2.9 +/- 0.5pg/mL; p0.01 respectively). Meanwhile, the serum cortisol and FT4 levels in the hemorrhage stroke group were higher than those of control group, but only cortisol level shown a significant difference (19.3 +/- 13.1 ug/dL versus 12.1 +/- 3ug/dL; p0.05). 61.7 percent patients had an increased serum cortisol; 54.1 percent and 31.9 percent had decreased TSH and FT3 respectively. The serum cortisol levels was associated with the severity of the disease. Conclusion: Cortisol increased and TSH and FT3 decreased in patients with hemorrhage stroke during the first 72 hours. The concentration of serum cortisol was associated with the severity of the disease.