Đặc điểm giải phẫu bệnh và một số yếu tố liên quan đến đột biến KRAS

To describe histopathological characteristics and some factors related to KRAS, BRAF mutations in colorectal cancer patients. Subject and method: A cross-sectional descriptive study on 120 colorectal cancer patients diagnosed and treated at the Institute for Treatment of Digestive Diseases, 108 Military Central Hospital from May 2017 to December 2020. Result: The most colorectal cancers were found in the left colon (39.2%), the majority of colorectal cancers were type 3 (infiltrative ulcer) with 35.8%, adenocarcinoma was predominant (86.7%), mostly moderately differentiated (69.2%). The rate of KRAS and BRAF mutations in colorectal cancer patients were 38.3% and 15.8%, respectively. There was no relationship between KRAS, BRAF gene mutations and histopathological features. Conclusion: Colorectal adenocarcinoma, the form of infiltrative ulceration accounted for the largest rate, the majority of colorectal cancer was moderately differentiated. There was no relationship between KRAS, BRAF mutations and histopathological features.