Đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị ở bệnh nhân người lớn sốc sốt xuất huyết dengue có tái sốc được sử dụng albumin tại Bệnh viện Bệnh Nhiệt đới

Dengue shock syndrome is one of the most severe form of dengue infection. In patient with recurrent shock, not responding with standard fluid perfusion, treatment with albumin was proposed to avoid developing many episodes of recurrent shock, to avoid overload fluid and respiratory distress in the reabsorbtion phase. Appropriate use of albumin in patients with recurrent shock need to be assessed carefully. Objectives To describe the clinical manifestations, laboratory features and outcome in adult patients with dengue recurrent shock being treated with albumin at the Hospital for Tropical diseases from 01/11/2019 to 15/11/2020. A case report study. Dengue patients diagnosed of having recurrent shock were enrolled of the 17 cases recruited in the study, female patients were 14/17 (82.4%). Results Of the 17 cases recruited in the study, female patients were 14/17 (82.4%) with the median age of 22 (IQR 17; 29). All patients had fever, 12/17 (70.6%) had abdominal pain, 8/17 (47.1%) had vomiting, and 6/17 (35.3%) had mucosal bleeding. 1/17 (5.9%) patients had only one episode of recurrent shock; the percentage of patients with two, three and four episodes of recurrent shock were 47.1% (8/17), 35.3% (6/17) and 11.8% (2/17), respectively. The median value of albuminemiae was 18.8 (16.4; 22.6) g/l. By perfusing albumin, 13/17 (76.5%) patients had no more recurrent shock. There was no statistically significant association between age < 20 yrs, sex, BMI, previous history of having a dengue infection, and having a fever during shock with the risk of recurrent shock  2 times. Conclusions There was an important decrease of albumin in dengue patients having recurrent shock. The use of albumin avoid an onother episode of recurrent shock in 76.5% of cases.