To control the vommit symptom give more successful and easier to oral fluid infusion, reduce the cost and work if using IV infusion. All over the world there are many studies on using Ondansetron for vommint preventing in gastroenteritis in children and show the effectiveness and safety. At Hue, Ondansetron mainly use for vommit preventing for children patients treated by chemotherapy and radiotherapy. There was no study about using Ondansetron to vommit preventing and treating for children patients with acute gastroenteritis. The aim of this study is to evaluate the effectiveness of Ondansetron in vommit treating for children with acute gastroenteritis. The study was carried out on children from 6 mths to 5yrs with acute gastroenteritis at Pediatric department of Hue Central Hospital. Using the method of dinical intervention with control group. 2 groups had the similarity of age, gender, onset duration of vommit, dehydration situation. Sample size: 86 children in control group and 41 children for study group. Study group (with intervention): only one shoot Ondansetron 0,2mg/kg + treatment plan fordedration + Zinc suppement as IMCI guidelines. Control group: treating by treatment plan for dehydration (Plan A if not having dehydration, plan B if having some dehydration) + Zinc suppement as IMCI guidelines. Both two groups will follow up about the situation of vommit, watery stools and the amount of ORS, the amount of N fluid. The rate of patient without vommit in the time from intervention to hospital discharge: Group having Ondansetron was 56.1 percent in comparision with 5.8 percent in control group (p 0.01). The study group had the rate of patient with vommit or = 3 times was 7.3 percent lower than the rate of 54.7 percent in control group (p 0.05). The avarage time of vommit in control group was higher than study group (0.71 + or - 0.96 vs 2.45+ or - 1.12, p 0,05). The rate of patiend need IV infusion in study group was 9.8 percent, control group was 37.2 percent (p 0.05; RR
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