Background: International Pediatric Sepsis Consensus Conference in 2002 (IPSOC 2002) in the United States has taken guidelines for sepsis and septic shock in children: identify early signs of shock, fluid bolus resuscitation, and rational use of vasoactive drugs. This guidelines were effective to reduce mortality in pediatric septic shock. Objectives: To evaluate the effects of vasopressors on hemodynamic parameters of pediatric septic shock. Methods: Non-controled, clinical trial. One hundred and two patients, aged from 1 month to 15 years old with septic shock, admitted to the pediatric intensive care unit of the National Hospital of Pediatrics from January, 2012 to December, 2009. the authors used the IPSCC 2002 guideline for management of septic shock. Patients were divided in the three groups: Group I: fluid-resistant, dopamine-responsive shock; Group II: fluid-resistant, dopamine-resistant shock; and Group III: Catecholamine-resistant shock. Vasopressror-responsive parameters such as heart rate, mean blood pressure, mottled and cold extremities, pH etc were compared among groups. Results: Normalized systolic blood pressure was increased from 7.8 percent to 48.0 percent after 6 hours, increased mean blood pressures to target values were from 25.5 to 70.6 percent. Improvement in capillary refill time, cold extremities, urine output, arterial pH was noted. Dopamine response: was noted in 30.4 percent patients, response to Adrenaline and/or noradrenaline was seen in 20.6 percent. Catecholamine resistant was seen in half of the patients. Conclusion: Using wasopressors in the management of septic shock improved clinical parameters and arterial pH.
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