Đánh giá tác dụng của Clozapine lên một số hoạt động vận động, tương tác xã hội của chuột nhắt gây mô hình bệnh tâm thần phân liệt

The study was conducted on 45 healthy male white mice, weighed 20-30 g. The purposeof the study was evaluating the effect of clozapine on locomotor activities, social interactions in mice modeled for schizophrenia.Animals were divided into 3 groups of 15 each. The control group was injected with saline (10 ml/kg/day), the ketamine group was injected with ketamine (20mg/kg/day) all for 14 consecutive days. The western medicine group of 15 mice was injected with ketamine (20 mg/kg/day)for 14 consecutive days, then taken orally clozapine dosed 5 ml/kg/day continuously for 30 days. The results showed that after injection of ketamine mice expressed some manifested behaviors similar to schizophrenia symptoms in human. Clozapine used to treat the modeled mice showed some positive outcomes, such as reducing immobility numberand increasing social interaction time.