Infection of pancreatic necrosis has a major impact on clinical course, management and outcome in acute pancreatatis. Objectives: The aim of this study is to asess serum procalcitoin for early prediction of severe and infected necrosisis in acute pancreatitis. Methods: From 11/2012 to 8/2013; 104 patients with acute pancreatitis in Bach Mai hospital confirmed by radiological evidences, laboratory assessments, and dinical manifestation were prospectively enrolled. All blood samples and image studies were obtained within 24hours ofadmisson. PCT was measuredprospectively by a semi automated immunoassay and CRP was routinely assessed. Results: Acute pancreatitis was graded as severe in 25,9 percent patients, and mild in 74,1 percentpatients according to the .Atlanta criteria. Median concentration of per was 8,24 20,79ngjml. Levels of serum per were significantly higher in severe acute pancreatitis (29,55 + or - 33,18ngjml), necrosis (16,38 + or - 25,73ngjml), fever (13,74 + or - 27,77ngjml) with p0,05. The most effective cut off level of serum per was estimated at 0,965 ngjml. In comparison to CRP, serum PCT had more accurate value (AUROC
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