Nephritis and kidney failure are the leading cause .of morlality in systemic lupus erythematosus (SLE). The effect of intravenous cyclophosphamide pulse therapy on nephropathy in 12 SLE patients was evaluated after 1, 3 and 6 months. The results indicated that clinical manifestations including fever, arlhritis, and peripheral edema were improved significantly. The concentration of hemoglobin as well as total serum protein and albumin increased significantly while urine protein/24 hours decreased clearly. The stage of kidney failure was stable during 6 months. Side effect was observed in two cases of uterus cervical papilloma. These results provided evidences of beneficial effect of intravenous cyclophosphamide pulse therapy on improvement of nephropathy in SLE patients. the results also supported a prominent role of cyclophosphamide in the management of severe, life-threatening manifestations of SLE.
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