To establish a primate animal model of schizophrenia with negative symptoms, behavioral effects of chronic phencyclidine (PCP) and additional acute methamphetamine (MAP) administration were investigated using 6 monkeys. They were divided into 2 groups consisting of the control (3 monkeys) and the PCP injected group (3 monkeys), raised in a room with the stable temperature at 23oC and 12/12 light/dark cycle. They were fed ad libitum with food and water. The PCP group monkeys were chronically injected with PCP (dosed 0.3 mg/kg/day) during 7 months, and injected with MAP (dosed 2.0 mg/kg/day) on the behavioral testing day. The apparatus was a chamber jointed by 3 seperated boxes that was cover by a transparent plexiglass allowing observing and recording monkey behaviors by a CCD camera on the ceiling of the experimental room. The behaviors of the monkeys were analyzed automatically by a commercial software from Clever Sys company, US. The behavioral analyzing software could detect over 15 social and individual behaviors of the monkeys in the recording room. The results indicated that chronic PCP treatment induced a significant decrease in all categories of the social behaviors, and that the chronic PCP monkeys also spent less time in proximity to other monkeys than the control monkeys. Acute MAP injection to the chronic PCP monkeys exacerbated behavioral effects of PCP The results suggest that these monkeys can be used as a primate animal model of schizophrenia with negative symptoms.
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