Kết quả kích thích buồng trứng nhẹ bằng Clomiphene Citrate kết hợp FSH trên bệnh nhân thụ tinh trong ống nghiệm giảm dự trữ buồng trứng tại bệnh viện Phụ sản Trung ương

This is a retrospective study on diminished ovarian reserve patients, undergoing mild ovarian stimulation, from August 2020 to August 2022 at the National Hospital of Obstetrics and Gynecology to investigate the oocytes and embryos in 2 groups (group I: Clomiphen Citrate at 100 mg/day combined with 150UI - 225UI FSH; group II: Clomiphen Citrate at 150 mg/day combined with 150UI - 225UI FSH). Results showed that the average FSH dose in group I was 168.6 ± 28.9 UI/day; group II was 164.7 ± 22.1UI/day. The number of obtained oocytes and MII oocytes of group I (5.8 ± 4.9 and 4.7 ± 3.9) were higher than group II (5.0 ± 2.6 and 3.8 ± 2.1). Total number of embryos obtained from group I was 3.8 ± 3.1, which was higher than group II, 2.95 ± 1.6. However, the difference in the number of obtained embryos between the 2 groups was not statistically significant (p > 0.05). Thus, mild ovarian stimulation is a potential approach for patients with diminished ovarian reserve where Clomiphen Citrate at 100 mg/day or 150 mg/day gave similar results.