Khảo sát nồng độ Kidney Injury Molecule-1 trong nước tiểu ở bệnh nhân đái tháo đường týp 2 có biến chứng thận tại Bệnh viện 19-8 Bộ Công an

Diabetes mellitus is one of the most common non-communicable diseases globally. It is predicted that by 2040, this number will increase to about 642 million people; of which, many type 2 diabetic patients have been ill for a long time and do not know, leading to serious complications, of which kidney complications are considered the most dangerous and expensive. The current assessment of kidney disease in diabetic patients is determined by the change in the concentration of microalbuminuria (MAU). Microalbuminuria is currently considered a marker of high sensitivity and specificity in diagnosing kidney damage at this stage, but MAU may also appear in cardiovascular diseases. Finding a biomarker that can assess kidney damage before microalbuminuria changes and glomerular filtration rate is what many studies have focused on. Recently, many studies have found many valuable biological markers in the early diagnosis of diabetic kidney damage, including Kidney Injury Molecule - 1 (KIM1). Objective Find out the relationship between the concentration of KIM-1 in urine with some clinical and subclinical indicators in patients with type 2 diabetes. Subjects and methods Cross-sectional descriptive study on 61 patients with type 2 diabetes to be examined and treated at the Endocrine Department, 19-8 Hospital Department of Public Security and a control group of 30 healthy people. Conclusion KIM-1 concentration increased gradually f-rom healthy controls (57.29 ± 25.91 pg / ml) to diabetes group with uACR 30 mg / g (203.72 ± 59.49 pg / ml), the difference was statistically significant (p 0.05).