Aims: Studying the prevalences of HBV genotypes in chronic hepatitis B patients and their relation to HBeAg and HBV DNA level. Methods: 81 patients were enrolled in this study from Jan. 2009 to Dec. 2010. Clinical, laboratory data were collected at the hospitalized time. Sera were tested for HBeAg, HBV DNA quantitative. HBV genotyping was made by Real-time PCR. Results: Among 81 patients, 60.5 percent have genotype B, 26.7 percent have genotype C and 8.6 percent have mixed genotype B-C. Prevalence of symptoms (fatigue, anorexia, insomnia...) in genotype C higher than genotype B. Genotype C patients have HBeAg positivity higher than genotype B patients (56 percent vs. 38.8 percent, p 0.05). The rate of HBV DNA 107 copies/mL in genotype C group higher than genotype B group (36 percent vs. 28.6 percent, p 0.05). Conclusions: Most of patients have genotypes B or C. Patients with genotype C have HBeAg positivity and may be related higher serological HBV DNA level than genotype B.
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