Nghiên cứu biến đổi chức năng lọc máu của thận ở bệnh nhân tăng huyết áp nguyên phát

Background: hypertension is the important factor to kidney disease progression and prevents cardiovascular risk. HTA cause GFR decrease. The target blood pressure below 130/80 mmHg[3] can improve renal function. Patients and Method: 228 case studies of primary hypertension fIowup by GFR test. Result and ConclusIon: men 50 percent, age average 59.3 + or - 9.6; women 50 percent, age average 59.1 + or - 9.1. Systolic blood pressure (mmHg) 168.9 + or - 11.8. Diastolic blood pressure (mmHg) 95.4 + or - 8.1. The mean blood pressure (MBP) (mmHg) 119.9 + or - 9. 3. Glomerular filtration rate (GFR) decreased more in HTA compared with normals (88.4ml/mn/1.73m2 compared with 90.6 ml/mn/173m2) but no statistically significant p = 0.31. Glomerular filtration rate in hypertensive grade 1 is higher hypertension of grade 2 and 3 (94 ml/mn/1, 73m2, compared with 86 and 77 ml/mn/1,73m2) with statistical significance p=0.04, p=0,004. GFR correlate well with blood pressure, r = 0.331, P = 0.003 correlation formula: GFR = 156.9 0.57 x MBP.