Nghiên cứu cải thiện tốc độ hoà tan itraconazol áp dụng trong bào chế nang cứng

That itraconazole (lTZ) commonly used as an antifungal agent of broad spectrum of activity, but of extremely poor solubility initiated this study to improve its dissolution rate by forming a complex with 2-hydroxypropyl-beta-cyclodextrin (HPBCD). The process was quantitatively validated proving to meet requirements for linearity (8-28 ug/ml), precision (RSD 2 percent) and accuracy (80-110 percent). The proportion between ITZ and HPBCD of 1:2 was best suitable. Dissolution tests showed the complex containing the 5 percent of additive K prepared by kneading (40 min) had a significantly high dissolution rate (79.4 percent after 60 min). Moreover, changes were recorded in its spectra (lR, DSC, 1H-NMR) and melting point. Also, capsules containing ITZ-HPBCD complex had much better dissolution rate (76.56 percent after 45 min).