Background: CLL is a common lymphoid malignancy. Several new chemotherapy protocols have been introduced for treatment of CLL recently, includlllg FC protocol. Purpose: To assess the effectiveness of the FC protocol for treatment of CLL patients. Patients and methods:. Study was carried out on 42 CLL patients treated in NIHBT from 12/2009 to 11/2012. Results: (1) Complete response rate was 47.6 percent; overall response rate (complete and partial response) was 83.3 percent; (2) Clinical condition was improved: percentage of patients with anemia, splenomegaly and Iymphodenopathy before and after treatment were 85.7 percent and 11.9 percent; 71.4 percent and 9.5 percent; 92.8 percent and 4.8 percent, respectively; (3) Peripheral blood lymphocyte count was decreased gradually and normalized after treatment; (4) Hematological adverse effects: Neutropenia and thrombocytopenia grades 1-2 have been observed in 42.8 percent. Few patients have severe neutropenia (grade 3 - 4.7 percent) and thrombocytopenia (grades 3-4 - 7.1 percent and 4.7 percent, respectively). Conclusion: FC is an effective chemotherapy protocol for treatment of CLL patients.
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