Nghiên cứu độc tính của dịch chiết húng quế (Ocimum Basilicum L) đến điện tâm đồ ở thỏ thực nghiêm

To assess the effects o f aqua basil extract (Ocimum basilicum LJ on experimental rabbits' electrocardiograms w ith a continuous oral regimen of 28 days. Subject an d M ethods: The Vietnam M inistry o f Health's and OECD's guidelines for sub-chronic toxicity testing were applied. The aqua basil extract was treated orally in tw o different groups w ith dose regimens o f 0.6 and 1.8 g/kg/day X 28 consecutive days, respectively. A control group treated orally with distilled water was also tested simultaneously. The rabbit's electrocardiograms were recorded on days NO (before taking samples), N14 and N29 (after finishing the treatment) in 12 leads (3 leads bipolar limb, 3 leads unipolar limb, 6 leads thoracic). Evaluation indicators include heart rate, p wave, PQ interval, QRS complex, T wave, QTinterval, and other signs (if any). Results: With the two dose regimens o f 0,6 and 1,8 g per kg per day for 28 consecutive days, the aqua basil extract did not significantly change rabbits' heartbeats and cardiovascular waves (such as p, QP, QRS, T and QT) through study days (DO, D 14 and D29). These indices did not differ significantly among the treated and control groups (the p values > 0.05). Conclusion: The aqua basil extract (at the two oral doses o f 0,6 and 1,8 g/kg per day for 28 consecutive days) was safe in rabbits' cardiovascular systems.