Objective: The result of' survival rates in neoadjuvant chemotherapy with cisplatin and 5 f1uorouracil in patients with stage III-IV(MO) mobile tongue cancer followed by surgery and/or radiation. Patients and Methods: 117 caSes with stage IIIIV(MO) mobile tongue cancer, were investigated in this prospective study, treated by neoadjuvant chemotherapy with CF regimen followed by surgery and/or radiation at K hospital and Ha Noi medical university hospital from 2002 to 201.0. Result: Overall 01year, 02 year, 03 year, 04 year 'survival rate were 75,2 percent; 57,5 percent; 45,2 percent; 39,2 percent. The five-year survival rate was 22.4 percent. The five-year survival rate for stage N0 was 27,2 percent and N1-N3 was 13,3 percent ( p 0,05). The five-year survival rate for stage III was 42.5 percent and stage IV was 11.3 percent ( p 0.05). The five-year survival rate for chemotherapy plus surgery group and chemotherapy plus radiotherapy were 33.1 percent vs 11 percent. The five-year survival rate for chemotherapy plus surgery group and chemotherapy, surgery plus radiotherapy group and chemotherapy plus radiotherapy were 32.4 percent; 32.2 percent vs 7.3 percent percent. Conclusions: Result treatment with stage III-IV(MO) mobile tongue cancer with neoadjuvant chemotherapy improved the rate of tumour response, many patients could be treated by surgery after neoadjuvant chemotherapy. Neoadjuvant cisplatin and 5 fluorouracil regimen improves survival in tongue cancer patients.
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