Nghiên cứu mối liên quan giữa đặc điểm tổn thương động mạch vành ở bệnh nhân bệnh thận mạn giai đoạn cuối bằng chụp vi tính đa lát cắt với một số yếu tố nguy cơ tim mạch truyền thống

Introduction and objectives: Cardiovascular disease is the main cause of mortality in patients with end-stage renal disease (ESRD). The traditional cardiovascular risk factors of coronary artery disease in chronic kidney disease are multifactorial, including hypertension, hyperlipidemia, diabetes mellitus, age, gender, body mass index, smoking history and family history of coronary artery disease. The,purpose of this study is to determine the relationship between coronary artery lesions in ESRD patient demonstrated by multi-slice computed tomography (MScr) coronary angiography and traditional cardiovascular risk factors. Patients and methods: In total, 105 patients were included in the study, the mean age of the participants was 55.6 + or - 16.9 years; 46 males (43.8 percent); 46 patients with diabetes (43.8 percent); 101 patients with history of hypertension (96.2 percent), the mean of body mass index 21 + or - 3.1 kg/m2, 31 with smoking history (29.5 percent) and 27 patients with family history of coronary artery disease (25.7 percent). Results: CACS was 0 in 47 patients (44.9 percent), 1-100 in 32 patients (30.5 percent) and 101-1000 in 26 patients (24.7 percent). CACS was evaluated in relation to traditional risk factors in patients with end-stage renal disease. Age was associated with CACS 100 (p: 0.019), lesions with or = 50 percent stenosis LAD (p: 0.001) and atherosclerosis plaque (p: 0.000 with T-test). History of diabetes mellitus was associated with CACS 100(p: 0.003), lesions with or = 50 percent stenosis LAD (p: 0.000), LCX (p:0.000), RCA (p: 0.000) and atherosclerosis plaque (p: 0.000 with T-test). Body mass index was only with atherosclerosis plaque (p: 0.034 with T-test). Family history of coronary artery disease was related with CACS 100 (p: 0.086), lesions with ~ 50 percent stenosis LAD (p: 0.023), LCX(p:0.000), RCA(p: 0.028) and atherosclerosis plaque (p: 0.001 with T-test). History of hypertension, gender and smoking history were not associated with coronary artery lesions and atherosclerosis plaque. Conclusion: There is a relationship between coronary artery lesions in end-stage renal disease patient demonstrated by MSCT angiography and traditional cardiovascular risk factors such as age, history of diabetes mellitus, body mass index, family history of coronary artery disease.