Nghiên cứu mối liên quan kiểu gen với đặc điểm lâm sàng và các dấu ấn vi-rút ở bệnh nhân viêm gan vi-rút B mạn tính

Backgrounds: The association of HBV genotypes with clinical outcomes is increasingly concerned. Aims: to determine HBV genotypes and the association of those genotypes with virologic and clinical characteristics in patients with CHB infection. Subjects and methods: a prospective and crosssectional study investigated 62 patients with CHB infection. HBV genotypes were determined by RFLP-PCR technique. Results: There were 7 single genotypes and 6 genotype mixtures. HBV single genotype distribution in the group: A(14.5 percent), B(16.1 percent), C(59.7 percent), D(6.5 percent), E(1.6 percent), F(3.2 percent) and G(12.9 percent). The serum ALT levels, HBV-DNA and hepatitis B e antigen positivity were significantly higher in patients infected with genotype C HBV than in those infected with genotype B (P0.05). Meanwhile, the serum transaminase and bilirubine levels were significantly less in patients infected with genotype G than in those infected with other genotypes. Conclussions. Genotypes Band C are the the most common types among hepatitis B carriers in Vietnam and those genotypes influence the clinical manifestation in patients with chronic hepatitis B.