Nghiên cứu mức độ ứ sắt trong gan trong bệnh Thalasemia trên chụp cộng hưởng từ 1.5 Testla

Background and Purpose: MRI is a noninvasive technique that can explain the drop signal of hemochromatosis due to the superparamagnetic characteristics of iron. Therefore we conducted this study aims to measurement of iron accumulation in MRI liver compared with serum ferritin in patients with thalassemia. Subjects and Methods: 20 thalassemia patients taken MRI (Avanto 1.5 Tesla Siemens) at the Department of Imaging, Bach mai Hospital from 12/2011 to 08/2012. Perform 5 pulse sequence gradient echo at the middle liver. T1-W (120/4/900), Proton density (120/4/200), T2-W (120/9/200), T2 * (120/14/200), T2 * (120/21/200). Each pulse sequence signal measurements in five regions: three the liver and two para-spinal muscles sides. Analyze and evaluate the relationship between the two variables on the level of hemochromatosis on MRI liver with serum ferritin. Results: 15/20 patients with hemochromatosis severity, 4/20 have hemochromatosis moderate, 1/20 with mild hemochromatosis. 14/14 patients with ferritin of 2500 ng/ml with hemochromatosis severity. The correlation coefficient quite closely between liver iron concentration and ferritin with R = 0.587 (R2 = 0.345). Conclusion: MRI can determine the degree of liver hemochromatosis using both qualitative and quantitative (LIC calculations). This method detect level accumulation of iron in the liver, even mild, in thalassemic patients.