Background: Type 2 diabetes is on the verge of becoming a pandemic on the world, specially in developing countries. Homocysteine, a thiol containing amino acid, related research has generated a vast amount of literature and sparked a vigorous debate over the past decade. Hyperhomocysteinemia in type 2 diabetes make to a double risk factor create to increment complications. Objectives: The aim of the study was to evaluate the levels of homocysteine and to examine the relationship of Hcy level with ages, gender and period of diseases in type 2 diabetic patients. Methods: a cross - sectional, descriptive study was carried out on 110 patients of Friendship Hospital (55 in type 2 diabetic patients and 55 in nondiabetic patients) from 5/2011 to 4/2012. Results and Conclusions: Plasma Hcy levels in type 2 diabetic patients were significantly higher than in nondiabetic patients (13,05 + or - 4,77 vs 11,40 + or - 2,9 umol/l, p=0,031); Plasma Hcy levels in type 2 diabetic patients were increment of ages: 60 ages: 11,15 + or - 3,73; 60-70 ages: 11,67 + or - 3,48 and 70 ages: 15,53 + or - 5,76 umol/l (p = 0,011); Plasma Hcy levels weren't differences between male and female in type 2 diabetic patients. Plasma Hey levels in type 2 diabetic patients affected from 5 years, 5 - 10 years, 10 years were a similar trend (p 0,05).
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