Nhân chín thường hợp động kinh cục bộ kháng thuốc ở trẻ em được điều trị kết hợp nội và ngoại khoa tại bệnh viện Nhi Trung ương

Drug-resistant localization-related epilepsies are a heterogeneous group of diseases characterized by partial-onset seizures, nonresponsiveness to pure medical treatment and the presence of an underlying epileptogenic lesion. Objective: To describe clinical manifestations and some chacteristics of the epileptogenic lesion in nine children suffering from drug-resistant localization-related epilepsies who have received both medical and surgical treatment. To remark the initial outcome of the abovementioned treatment. Result: Nine children with drug-resistant localization-related epilepsies have been treated medically and surgically at National Hospital of Pediatrics over a two-year period (2010-2012). Anatomically, temporal lobe involvement accounts for 55.5 percent of cases (5/9) and frontal lobe or multi-lobar involvements account for the remaining 44.4 percent (4/9). Histopathologically, lowgrade tumors: 33 percent, FCD: 33 percent, hippocampal sclerosis: 11 percent, acquired cerebral hemiatrophy: 11 percent and unremarkable: 11 percent. The initial success rate stands around 72 percent. Conclusion: Drug-resistant localization-related epilepsies in children could be cured radically by surgery combined with medical treatment.