Nhận xét kết quả điều trị sau 3 tháng sử dụng liệu pháp tế bào gốc tủy xương tự thân hỗ trợ điều trị bệnh teo mật bẩm sinh tại Bệnh viện Nhi Trung ương

To evaluate the early outcome of the autologous stem cell transplant (ASCT) in the treatment of billary atresia (BA) in Vietnam National Children’s Hospital. Subjects and methods: this is a prospective case-series, enrolled 31 patients diagnosed with BA, they were treated with Kasai surgery in combination with ASCT in Vietnam National Children’s Hospital from May 2021 to April 2022. Results: 31 patients were enrolled in the study, amongst those there was only 1 patient who did not fully follow the research. The ratio of male: female was 1:1. The mean age at the time of surgery is 78.8 days old. Prior to the treatment, 100% of the patient had jaundice and white or pale stool; both of these two signs were reduced at 3 months post-op, respectively (p < 0.001). There is a statistically significant difference in the level of total billirubin, conjugated billirubin, ALP and GGT between pre-op and 3-month-post-op (p < 0.01, p < 0.01, p < 0.01 and p < 0.05, respectively). At 3-month post-op, 40% of the patients had complete bile flow, 61.29% of the patients suffered from cholangitis. The median of APRI score of the pre and post-op was 0.82 and 1.16, respectively (p > 0.05); the mean PELD score of the pre-surgery and post-surgery was 9,26 and 3.83, respectively (p < 0.05). Conclusion: there is a significant improvement in the clinical manifestation, laboratory findings and PELD score after the ASCT in the treatment of BA. In the future, we would like to conduct a similar research with a bigger population and longer follow-up duration in order to fully evaluate the outcome of this therapy.