Nồng độ PTH và Calci huyết tương ở bệnh nhân ung thư tuyến giáp thể biệt hóa sau phẫu thuật triệt căn tại Bệnh viện Trung ương Thái Nguyên

Determine of plasma PTH and total calcium in patients with differentiated thyroid cancer before and after thyroidectomy at Thai Nguyen National Hospital during the period of 2023-2024. Subjects and methods: A cross-sectional, with longitudinal follow-up of 65 patients diagnosed with differentiated thyroid cancer after thyroidectomy at Thai Nguyen National Hospital between April 2023 and April 2024. Results: The mean age of the patients was 45.5 years, with females comprising the majority (92.3%). Postoperative histopathological analysis predominantly revealed papillary thyroid carcinoma, accounting for 95.4% of cases. The majority of patients underwent total thyroidectomy (90.8%) and central neck dissection (66.2%), with an average surgical duration of 93.87 minutes. The fluctuations in PTH levels at preoperative, postoperative 1 day, and postoperative 1 month were 40.43 pg/mL, 19.84 pg/mL, and 36.41 pg/mL, respectively. Similarly, the fluctuations in total calcium levels at preoperative, postoperative 1 day, and postoperative 1 month were 2.31 mmol/l, 2.12 mmol/l, and 2.27 mmol/l, respectively. The highest incidence of postoperative hypocalcemia occurred on postoperative 1 day, accounting for 35.4% of cases. Conclusion: Following total thyroidectomy, plasma PTH and Calci total levels exhibited consistent reductions compared to preoperative levels (p<0.05). The most pronounced decreases were observed on postoperative 1 day, with partial recovery noted at 1 month postoperatively.