Aim: Evaluation the effects of blood pressure (BP) reduction and adverse effects of lercanidipine in hypertensive patients complicating ischemic stroke in acute phrase by ABPMs' technique. Methods: 52 hypertensive patients with complications of cerebral infarction were followed up 24-hour BP (ABPM) in the first week, then use lercanidipine 20 mglday for 4 weeks and then take the second ABPM. The program was measured every 30 minutes at a time day (6am-10pm) and 60 minutes at night (10pm-6am). Results: After 4 weeks taking lercanidipine, BP in hypertensive patients with complications of cerebral infarction was significantly reduced (p 0.001): 17 + or - 10/8 + or - 9 mmmHg for 24 hours blood pressure, 18 + or - 11/8 + or - 9 mmHg for time day and 14 + or - 16/7 + or - 12 mmHg for night. Pulse pressure reduced 9 + or - 10 mmHg for 24h. The response rate was 34.6 percent and the normalized rate is 30,8 percent. The early morning BP ratio and overload ratio was significantly reduced. The rate of patients with adverse events was 5.7 percent. Conclusion: Lercanidipine significantly reduced 24-h BP, daytime, night in hypertensive patients with complications of cerebral infarction. Evaluation of the effects of the drug by ABPM is reliable and more benefits of clinical BP measurement. Lercanidipine effect lasting 24 hours and significantly reduced the rate of early moming and BP overload rate. The rate of side effects of lercanidipine is low.
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