Tái mở ống động mạch sau dự phòng tồn tại ống động mạch bằng paracetamol tĩnh mạch ở trẻ sinh non ≤ 27 tuần có bơm surfactant

To determine the rate of reopening of the ductus arteriosus after successful PDA prophylaxis with intravenous paracetamol in premature infants ≤ 27 weeks associated with RDS receiving surfactant therapy. Methods: A retrospective - prospective study of all infants who achieved successful closure of the ductus arteriosus after PDA prophylaxis with intravenous paracetamol from April 1st. 2018 to February 28, 2021 at NICU of Children's Hospital 1. Results: There were 31 patients who achieved successful closure of the ductus arteriosus after intravenous paracetamol prophylaxis. During the hospital stay, there were 7 (22.6%) cases of re-opening of the ducts requiring PDA closure, the mean time of PDA reopening was 14 days postnatal age, the incompletely PDA closure, and female gender were two factors that increase the rate of PDA reopening. Conclusions: The ductus arteriosus reopened in at least 22.6% of infants after successful PDA prophylaxis with intravenous paracetamol. Therefore, PDA should be monitored by clinical assessment and cardiac ultrasound for early detection of symptomatic PDA requiring intervention, especially during the first 2 weeks of postnatal age in incompletely PDA closure patients.