Tỷ lệ mắc bệnh, yếu tố liên quan với viêm màng não trên bệnh nhân nhiễm trùng huyết sơ sinh tại Bệnh viện Nhi Đồng 1

Neonatal meningitis is one of the leading causes of mortality or sequelae in newborns, needs to be diagnosed and treated promptly. Neonatal meningitis have coexistent neonatal sepsis (25%). Objectives: This study aimed to determine: (1) incidence rate of meningitis in neonatal sepsis at the Children’s Hospital 1; (2) epidemiological, clinical, laboratory c-haracteristics and risk factors of meningitis in neonatal sepsis. Methods: Cross-sectional study almost all cases were mature newborns with birth weights were equal or more than 2500 grams. Results: The incidence rate of meningitis in the neonatal sepsis f-rom 01-08-2019 to 31-05-2020 was 22.4%. Almost all cases were mature newborns with birth weights were equal or more than 2500 grams. The primary signs and symptoms were poor feeding (84.2%), fever (78.9%), lethargy (63.2%). CRP was higher than 40 mg/L in 63.2% of the cases. Cerebrospinal fluid (CSF) result showed: the number of leukocytes f-rom 20-99/mm3 in 63.1% of the cases, protein and glucose were invariable. Lethargy was an independent factor related to neonatal meningitis. Conclusions: The signs and symptoms of neonatal meningitis were nonspecific, complete blood count and blood culture were low significance, suggesting the necessity of early lumbar puncture in neonatal sepsis, especially in the case of lethargy.