Tỷ số apolipoprotein B/apolipoprotein A-I và tình trạng xơ vữa động mạch trong sọ bệnh nhân nhồi máu não

Investigate the value of plasma apolipoprotein B/apolipoprotein A-I ratio in predicting Intracranial atherosclerosis (ICAS) in ischemic stroke patient. Subject and method: 259 ischemic stroke (IS) patients that were treated at Stroke Center-108 Military Central Hospital from 2/2021 to 6/2022. Patients were divided into 2 groups: IS group with ICAS including 81 patients and group without ICAS including 178 patients. The patients were clinically examined, having CTA or MRA, taking apolipoproteins and biological indicators tests upon hospitalization. Results: The ratio apoB/apoA-I of the ICAS group (1.19 ± 0.23 g/l) was higher than that of the NICAS group (1.03 ± 0.22) with p < 0.05. The concentration of apoB in the group with arterial occlusion (1.34 ± 0.24 g/l) was higher than in the group with moderate arterial stenosis (1.22 ± 0.23 g/l) with p < 0.05. The ratio of apoB/apoA-I in patients with arterial occlusion (1.21 ± 0.26) and severe stenosis (1.18 ± 0.26) was higher than in patients with moderate stenosis (1.04 ± 0.26) with p <0.05. The apoB concentration, apoB/apoA-I ratio of patients with one site stenosis, occlusion (1.22 ± 0.23 g/l; 1.06 ± 0.22) were lower than that of patients with multiple sites stenosis, occlusion (1.40 ± 0.26 g/l; 1.29 ± 0.25) with p < 0.05. In multivariate analysis of factors related to ICAS: ratio apoB/apoA-I (OR = 2.32; 95% CI 1.16 - 3.58; p < 0.05), metabolic syndrome (OR = 1.21; 95% CI 1.01 - 1.53; p < 0.05). Conclusion: The ratio apoB/apoA-I is an independent prognostic factor for ICAS in IS patients with p < 0.05.