The translocation of t(1;19)(q23;p13) is a poor prognostic factor, occurs in 3-5 percent of patients with B-cell acute lymphoblastic leukemia. There are two forms of t(1;19) translocation including balanced t(1;19) and unbalanced der(19)t(1;19), in there the unbalanced rates up to 75 percent and expected to be a better prognostic. From January 2011 to April 2012, fluorescent in-situ hybridization (FISH) technique was used to detect t(1;19) translocation of 9 patients with expression of E2A/PBXl by PCR technique in the Blood Transfusion and Hematology hospital. Results of the study showed that 44.4 percent of patients with balanced t(1;19) and 55.6 percent of patients with unbalanced der(19)t(1;19), in which a patients with balanced t(1;19) but there is an additional signal chromosome 1. FISH technique is technically simple, results in fast and with specific probes help accurately identify abnormality patterns of t(1;19).
- Đăng nhập để gửi ý kiến