Background: The Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault (CG) equations are commonly used for estimating glomerular filtration rate (GFR) on the worldwide; however, the MDRD equation has been not yet validated in Asia population. The aim of this study was to compare for valuate of the MDRD with CG equations for estimating GFR among diabetic patients 50 old years treating in Khanh Hoa and Dak Lak hospitals. Methods: The authors enrolled 107 hospitalized diabetic patients's average values for age (66.8 years), serum creatinine concentration (155,7 mmol/L), BSA (1.5m2), and male:female ratio (49:58). The study estimated GFR using the MDRD equation versus Cockcroft-Gault equation normalized to 1.73m2 to confirm their correlation coefficient, mean bias of eGFR in the age groups, sex and BMI as well as s the proportion of the stages of CKD follow the standard of National Kidney Foundation guidelines 2002. Results The pearson correlation coefficient between estimated GFR in MDRD and CG equations was r2 = 0.945. The mean eGFR of MDRD was 48,77 + or - 27,40 (mL/minute/1,73m2) and CG was 43,96 + or - 25,12 (mL/minute/1,73m2) with the median bias was 4.8 (95 percent CI 3.08 to 6.5) mL/minute /1.73m2. Non (significance between the mean eGFR in the 50-70 old groups, the CKD in stages IV and V, women and overweight subjets. Comparing for ( the proportion of the stages of CKD between two ( equations also showed not significantly different. Conclusions: The MDRD equation can be used for estimating GFR in local population in early detection and treatment of CKD to decrease the incidence of ESRD and cardiovascular disease.
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