Many risk factors have been proposed as predictors of CHD. New risk factors or markers are frequently identified and evaluated as potential additions to standard risk assessment strategies. The ACC/AHA has published a scientific statement on appropriate methods for evaluating the predictive value of new risk factors or risk markers. The scientific statement endorsed previously published guidelines for proper reporting of observational studies in epidemiology but also went beyond those guidelines to specifically address criteria for evaluation of established and new risk markers. The current writing committee endorses this scientific statement and incorporated these principles into the assessments for this guideline. The general concepts and requirements for new risk marker validation and evaluation in this document are briefly reviewed to provide a basis for the clinical pratice.
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