Xây dựng công cụ sàng lọc các thuốc có khả năng không phù hợp trên bệnh nhân cao tuổi tại Bệnh viện Đa khoa Trung tâm Tiền Giang

This study aimed to establish a list of potentially inappropriate medications (PIMs) that need attention on elderly patients by Delphi method and determine the inter-rater reliability (IRR). Method: The list of PIMs developed based on Beers criteria, STOPP criteria, drug list, literature search and Delphi process. The process of evaluating IRR includes 1 pharmacist (PIM list originator) and 1 physician (Delphi process) reached complete agreement in determining PIM of 20 clinical cases (rater 1); 2 pharmacists and 2 physicians (rater2-5) independently applied the list. IRR was determined using kappa statistic. Results: After two rounds, 85 criteria were accepted and 4 criteria were rejected. The median (Interquatile range - IQR) Cohen kappa coefficient between raters was 0,86 (0,85-0,87). The Fleiss kappa coefficient was 0,835 (95% CI: 0,835 - 0,836). Conclusion: The list of PIMs that need attention at the hospital has been developed, including 85 criteria with a specific active ingredient, risk theory and alternatives/suggestions. IRR of PIMs list is good, despite no prior knowledge of the list.