Objectives: 1. Describe the manifestation of depression in people aged 18-60 in six communes/districts of Hanoi, Thua Thien Hue and Can Tho in 2012; Describe the relationship between depression with some factors. Method: Cross-sectional study was carried out on 1200 people aged 18-60 in Ha Noi, Thua Thien Hue and Can Tho (2012). Calculation of the frequency/rate and also some statistical tests (X2, t-test, multiple regression and logistic regression) are done by Stata 10.0. Results: The rate of depression was 4.8 percent, with no difference between 3 provinces; Depression was found more in groups: Age 25-44 and 45-60; Farmers, Housewives/Retired people, Businessman; Widowed/Divorced group; Hard and hazardous job/work over 10 hours per day, and people had a family history of mental illness and chronic disease.
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