Đánh giá khả năng che phủ khuyết hổng xương của màng tim vô bào trên xương hàm thỏ

Decellularized pig pericardial tissue holds promise to perform better than immobilized and regenerated tissue, but cell degranulation has been shown to damage collagen structure and impair integrity. tissue mechanics. Objective: To evaluate the ability to cover bone defects of decellularized pig pericardial on rabbit jawbone. Materials and methods: Research object: Decellularized pig pericardial produced from pig pericardium at the Biomaterials Laboratory - University of Natural Sciences, Vietnam National University, Ho Chi Minh City Minh. - Commercial acellular pericardium: Decellularized pig pericardial XenoGide, NIBEC (Korea) has been licensed for use. Neobone Commercial Bones, Portugal. Experimental Rabbits: Healthy, Non-Purebred New Zealand Rabbits. Research location: Biomaterials Laboratory - University of Natural Sciences, Vietnam National University, Ho Chi Minh City. Research period: from July 2021 to August 2022.2. Study design: a double-blind experimental descriptive study. Result: - The results showed that after 3 months of transplantation: the bone healing process in the transplant group with decellularized pig pericardial was similar to that of commercial pericardium: the bone healed completely after 3 months. - No infiltration of fibrous tissue was detected in the bone marrow and very few inflammatory cells were present. Conclusion: The dPP Decellularized pig pericardial is a good support for the bone healing process in the maxillary defect in rabbits.