Định lượng đồng thời Paracetamol, Chlophenniramine maleate và Phenylephrine HCl trong thuốc Tiffy bằng phương pháp HPLC

Method of High Performance Liquid Chromatography (HPLC) is simple, selective, rapid, accurate and effective has been done to identify and paracetamol (PRC), chlopheniramine maleat (CPM) and phenylephrine HCI (PNH) in the pharmaceutical and medicine in general TTFFY using a mobile phase mixture of NaH2PO4 0.05 M : acetonitrile (volume ratio 93 : 07); volume sample pump is 20 uL with a mobile phase flow rate of 1.5 mL/min, using C18 column, measuring optical wavelength 2.15 nm and at a temperature of 30°C. The PRC quality, CPM and PNH in TTFFFY medicine has been successfully identified with the retention time of the PRC 8.62 second, the length of the CPM 2.78 seconds and the length of PNH 3.27 second. The recovery of the PRC is 99.7 percent; Recovery efficiency of CPM is 99.5 percent; and the recovery efficiency of PNH is 98.8 percent.