Hiệu quả của Colistin trong điều trị nhiễm khuẩn bệnh viện do vi khuẩn gram âm đa kháng tại khoa hồi sức tích cực nội bệnh viện Việt Tiệp, Hải Phòng

Objective: to evaluate the effects of Colistin in the treaments of nosocomial infections caused by pandrug resistant (PDR) Gram-negative bacteria. Methods: 16 patients with nosocomial infections caused by PDR Gramnegative bacteria at the medical ICU of Viet-Tiep hospital from 4/2012 to 3/2013 were treated with intravenous Colistin. Results: the mortality rate was 37.5; 9 cases caused by Acinetobacter (56,3 percent), 13 cases hospitalised acquired pneumonia (81,2 percent); 5 patients were treated Colistin combine imipenem and doxycyclin are successfully 100 percent, only 1 case increased renal failure. Conclusions: Colistin treatment in nosocomial infections caused. by PDR Gramnegative bacteria has the mortality rate 37,5 percent. Combine Colistin with imipenem and doxycyclin for a 100 percent success rate. PDR Klebsiella and Pseudomonas respond to treatment Colistin better than Acinetobacter. The side effects of treatment Colistin was rarely.