Hiệu quả dự phòng sinh non của progesterone kèm khâu vòng cổ tử cung ở thai phụ đơn thai tại Bệnh viện Mỹ Đức

Preterm birth is a global problem due to its long-term, serious consequences on mothers and neonates. Prevention strategy is critical to reduce the preterm birth rate. The commonly used strategy for prevention of preterm birth, nowadays, include the screening for risk of preterm birth which is a short cervix, and applying preventive measures such as vaginal progesterone or cervical cerclage. There is no study in which these two measures were combined to prevent preterm birth. Objectives To determine the rate of preterm birth before 37 weeks of gestation after using vaginal progesterone combined with cervical cerclage among singleton pregnant women who have a short cervix of ≤25 mm. Method This was a prospective case series conducted on 42 pregnant women having cervical length of ≤25 mm measured at 14 week0/7 to 24 week6/7 at My Duc hospital from October 2019 to July 2020. Results The rate of preterm birth <37 weeks was 28.6% and between 28–36 weeks was 19.1%. The mean birthweight was 2,852.4g; the rate of very low birthweight (<1,500g) and low birthweight (<2,500g) were 11.9% and 14.3%, respectively. The low apgar score of ≤3 was 2.4%. The mortality rate was 2.4% among the births. Conclusion The preliminary results have shown that vaginal progesterone combined with cervical cerclage may be effective for preventing preterm birth in singleton pregnant women having short cervix.