The study was to analyze results of treatment, the progress of open-heart surgery in 38 newborns with congenital heart disease at the National Hospital of Pediatrics for the period 2006 -2011. Results showed that of 38 infants whose average age was 16 days (3-33), average weight was 3.2 kg (2.1 to 4), the congennital heart defects intervene neonatal period mainly transposition great artery (TGA): 22/38 (57. 89 percent), pulmonary atresia (PA): 6/38 (15.79 percent), total anormalous pulmonary veins connection (TAPVC): 3/38 (7.89 percent), and some other defects 7/38 (18.42 percent). Results of treatment the survival rate was 81.58 percent, of which 77.27 percent success TGA patients, PA 100 percent, TAPVC 100 percent in period 2010-2011 25/38 newborn underwent open heart surgery, 88 percent survival, higher than the period 2006 - 2009 (69.23 percent). Complications after surgery were the most common pneumonia (68.42 percent), renal failure 21.05 percent, sepsis 10.52 percent, infection of the sternum 7. 89 percent. A number offactors affecting mortality are age 15 days (p 0.05), lactate level or = 4.4 mg/I (p 0.001), duration of CPB;:: 160 minutes (p 0.05), duration of aortic clamp or = 110 minutes (p 0.05). In conclusion, open heart surgery in newborn at National Hospital of Pediatrics had high survival rate. There have a lot progress in this field in recent years (2010-2011). It is need to aware of the complications after surgery such as pneumonia, kidney failure, sepsis, also a number of factors affecting mortality such as age, lactate level, duration of CPB time and duration of aortic clamp.
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