Khảo sát mối liên quan giữa HLA-B*1502 và phản ứng da do thuốc chống động kinh

Cutaneous reactions are the most common adverse reactions in antiepileptic drugs (AEDs). Some recent studies have reported that HLA-B*1502 allele is associated with an increased risk of carbamazepine and others - related cutaneous reactions. Objective: We investigated the frequency of HLA-B*1502 allele and the relation between HLA-B*1502 allele and AEDs-related cutaneous reactions in Vietnamese epileptic patients. Methods: This was a cross-sectional study with Vietnamese epileptic patients were treated with AEDs in Neurosurgery International Hospital f-rom April 2017 to September 2019. The patients who had taken AEDs for at least 2 months without developing cutaneous adverse reactions were AEDs-tolerant patients. Results: Among 259 subjects (56% men, 44% women, mean age at diagnosis 20.83 ± 13.79 years), the frequency of HLA-B*1502 was 25,9%. In cutaneous reaction patients, the ratio of this allele was 51,4% (75% in serious cases, 48,5% non serious cases) and the ratio in tolerant patients was 21,6%, the difference was statistically significant. Conclusion: In Vietnamese epileptic patients, the frequency of HLA-B*1502 was 25,9%, the presence of this allele was increased risk of AEDs - related cutaneous reactions.