Electro-physiologic studies are the most sensitive way to detect and to evaluate the progress of uremic neuropathy in patients who are receiving maintenance hemodialysis (HD). Objective: To study the electrophysiological changes of uremic neuropathy in HD patients. Patients and Methods: Electrophysiologic evaluation were performed in 30 patients of uremic on the duration of 6 months and 3 years of HD with longitudinal method (follow-up) and a paired comparison of electrophsiological parameters before HD versus 6 months and 3 years after HD treatment. Results: For the lower limbs, there were no significant correlations between the electrophysiological parameters and the duration of HD (6 months and 3 years) on the motor and sensory nerve conduction velocity, distal latency without amplitude (p0.05) in the peroneal, sural nerves and H-reflex. For the upper limbs, there were no significant correlations in the median nerves on the short-term (6 months) treatment (p0.05), but there were significant correlations on the long-term HD (3 years) treatment (p0.05). Conclusion: The severity of uremic neuropathy did not closely correlate with the short-term HD (6 months) and long-term HD (3 years) treatment.
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