Objective: Determine the sensitivity, specificity, positive predictive value and negative predictive value of D-dimer test in the diagnosis of cerebral venous thrombosis. Subjects: the authors selected 58 patients or = 16 years of age was diagnosed cerebral venous thrombosis at Cho Ray Hospital during January 2010 to May 2012. In the control group, the authors randomly selected 57 patients with a periodic health examination at Cho Ray Hospital. Methods: The prospective, cross-sectional descriptive study with the control group. Results: The mean + or - SD titers of D-dimer test in patients with CVT was higher than control group (1890,92 + or - 309,03 vs 146,19 + or - 15,55 ug/L), which were statistically meaningful (P 0,000). If the authors selected the cutoff level of D-dimer test at 302 ug/L, Positive D-dimer test was found in 91,33 percent of thrombotic and 10,6 percent of nonthrombotic patients. This was also statistically significant. Sensitivity, specificity, negative and positive predictive values and area under the ROC curve of the D-dimer test was 91,33; 89,47; 89,83; 91,07 and 0,904 , respectively. Conclusions: positive D-dimer test with high sensitivity and negative predictive value may be a useful diagnostic approach in patients suspected to have cerebral venous thrombosis. Negative D-dimer test can exclude thrombosis with a high certainty and MRI and/or MRV should preferably be performed only in patients with positive D-dimer test and highly suspected cases.
- Đăng nhập để gửi ý kiến