Increased concentration of homocysteine in the blood accounted for a high proportion of the population and related to increased risk of vascular disease. Objective: To study on concentration change of fasting total blood homocysteine level in patients with coronary artery disease; and on correlation between total blood homocysteine concentration in fasting with some risk factors for coronary artery disease. Subject and method: 52 patients with coronary artery disease was quantified fasting total blood homocysteine. Result: Average blood homocysteine concentration of patients with coronary artery disease was 14.11 +/- 3.91 umol/L, significantly higher compared with one of patients without coronary artery disease (11.16 +/- 4.33 umol/L) (p0.001); Hyperhomocysteinaemia was observed in 44.2 percent patients with coronary artery disease and 15.1 percent patients without coronary artery disease (p0.001). Conclusion: there was not a correlation between increased blood homocysteine with other risk factors; When blood homocysteine concentration is greater than 15 umol/L, it will increase the risk of coronary artery disease to 4.46 times.
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