Nghiên cứu tác dụng ức chế của chiết xuất tế bào gốc sâm Ngọc Linh đối với suy thoái collagen trong nguyên bào sợi bằng 2D-PAGE

The ability of Ngoclinh ginseng (NLG) stem cell extract in controlling the skin aging process in human fibroblasts was investigated. To evaluate the cosmeceutical effects of the extracts on the aging process, MTT assays were conducted with various concentrations of NLG stem cells. No extracts showed any cytotoxic activities on fibroblasts at concentrations of up to 10 mg/ml. An effect on the degradation of collagen matrix was observed when the dose concentration was 0.5 mg/ml. Proteome profiling analysis showed that the extract promoted the expression of proteins related to collagen production and suggested the skin aging effect of the extract. The extract could be considered as an attractive, anti-wrinkle ingredient for cosmetic applications.