Backgound: K-RAS gene mutations in colorectal cancers is a topical question and currently be interested by researchers in the World. However in Vietnam, this is not much studied. Objective: To determine the rate of K-RAS gene mutations in colorectal cancers. Subjects and methods: Crosssectional descriptive study on 68 patients with colorectal cancer. To determine the mutation of K-RAS gene by Scorpions - Amplification Refractory Mutation System (Scorpions ARMS) technique, performed in the Center for gene and protein research of Hanoi Medical University. Results and Conclusions: The rate of KRAS gene mutation in male patients is 36.7 percent and in female's is 22.1 percent (p 0.05). K-RAS gene mutation often be seen at the age from 50-79 years old with highest rate in group from 60-69 years old (17.5 percent); the highest rate of K-RAS gene mutation have been seen in moderately differentiated adenocarcinoma type (25.0 percent). The rate of K-RAS gene mutations when the tumors invaded in serosal, muscular and through serosal layer is 47.1 percent, 8.8 percent and 2.9 percent, respectively. The rate of K-RAS gene mutations is 16.2 percent in highgrade tumors and is 42.6 percent in low-grade tumors.
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