Objective: Determine the prevalence of nosocomial infection and common factorsassociated with nosocomial infection. Investigation of bacteria causing hospital infections and antibiotic resistance levels of bacteria. Methods: cross-sectional survey of random sample time, perform once on theincidence of infections and cases of old. The main study variable rate of nosocomial infection prevalence, associated factors, isolated bacterial infection, the level ofantibiotic resistance in bacteria. Results: In Khanh Hoa Hospital in 2010 showed that at the time of the survey 1000 patients eligible for study. Nosocomial infection rate: 4.1 percent, with three main types of nosocomial infection: Respiratory infection (36.6 percent), surgical site infection (24.4 percent), skin and soft tissue infections (22 percent). nosocomial infection related to a number of factors such as patient morbidities (p 0.05), preoperative status of patients rated ASA scale (p 0.05), the type of surgery clean, infection (p 0.05), peripheral catheters (p 0.05),ventiiation (p 0.05), hand health workers (p 0.05). Common pathogens caused nosocomial infection were Escherichia coli, Pseudomonas aeruginosa, Acinetobacter sp (23.08 percent),Klebsiella pneumoniae (15.38 percent), Enterobacter cloacae, Staphylococus aureus(7.69 percent). The level of antibiotic resistance of Escherichia coli, pneumoniae, Acinetobacter spp, aeruginosa (50-100 percent), cloacaeresistant to most antibiotics.
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