Objective: The purpose of this study was to assess the anesthetic safety and effectiveness of propofol administered for outpatients by Target - Controlled Infusion anaesthesia method (TO). Subject? and methods: the sample consisted of 60 patients aged from 18 to 70 years old with grade I or II in ASA classifications. All subjects, who were sent for colonoscopy or esophagogastroduodenoscopy, were received initial dose of propofol TCI 2.5 mcg/ml. The dose was then titrated according to clinical signs. Results: The complement time of the procedure was 23.7 +/- 11 minutes and the anaesthesia lasted for 28 +/- 7.5 minutes. The mean of plasma concentration (Cp) maintained during pr,?cedure was 2.9 +/- 0.25 mcg/ml, onset time at loss of consciousness was 68 +/- 12.4 minutes. Average doses of propofol, which were administered for induction and total procedure, were 58.8 +/- 15.5mg and 280 +/- 80.5mg, respectively. Heart rate and blood pressure decreased slightly and shortly after induction. The oxygen saturation, respiration rate were stable during procedures with minimal side effects. Full consciousness returned after 4.6 +/- 3.5 minutes and patients were discharged after 12.8 +/- 10.5 minutes with Aldrete score of 10. Conclusion: Using propofol TCI to induce and maintain anesthesia during colonoscopy and esophagogastroduodenoscopy was safe and convenient. 95 percent of surgeons and patients satisfied with the procedure.
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